|
Year:
2022 |
Month:
October
|
Volume:
11 |
Issue:
4 |
Page:
PO27 - PO30 |
Stromal Mast Cells in Invasive Ductal Carcinoma of Breast and its Relationship with Tumour Grade and Hormonal Receptor Status: A Cross-sectional Study
|
|
Correspondence
Sri Sughanya Chandra Sekaran, P Arunalatha, Dr. Sri Sughanya Chandra Sekaran,
No. 17, Rajiv Gandhi Nagar, Edamalaipatti Pudur, Trichy,
Tiruchirappalli, Tamil Nadu, India.
E-mail: c.srisughanya@yahoo.com :
|
|
Introduction: Tumour prognosis depends upon both the tumour cells as well as the stromal cells of the tumour microenvironment. Mast cells are immune cells which are basically involved in allergic reactions. But its role in breast cancer still remains controversial.
Aim: To identify the stromal mast cells in Invasive Ductal Carcinoma (IDC) of breast and its association with tumour grade and hormonal receptor status.
Materials and Methods: The present cross-sectional study was conducted in Department of Pathology, Government Stanley Medical College and Hospital, Chennai, Tamil Nadu, India with a sample size of 108 cases who had underwent Modified Radical Mastectomy (MRM) procedure for breast cancer between the period of November 2016 to April 2017. Patient age and sex was obtained from the histopathology requisition form. Histological grading of tumour based on Elston-Ellis modification of Scarff-Bloom Richardson grading system was done in Haematoxylin and Eosin (H&E) stained tissue sections. Giemsa stain was used to assess the stromal mast cells. All the 108 cases were screened for receptor status of Estrogen and Progesterone as well as Human Epidermal Growth factor receptor 2 (HER2neu) status through immunohistochemical staining. Results were analysed by Independent sample t-test and Chi-square test using Statistical Package for the Social Sciences (SPSS) software version 18.0.
Results: Of 108 study subjects, mean age of the subjects with mast cell positivity was 52.13 years and mast cell negativity was 53.01 years. Grade I tumour had higher proportion of stromal mast cell positivity whereas Grade III had higher proportion of mast cell negativity. Estrogen Receptor (ER) positive tumour showed association with mast cell positivity. There was no significant association between Progesterone Receptor (PR) positivity, Her2neu positivity and mast cell positivity.
Conclusion: Stromal mast cells in higher proportion were observed in low-grade tumour (Histological Grade I) when compared with high-grade tumour (Histological Grade III). Since stromal mast cells were associated with low-grade tumour, its presence suggested better prognosis. In this study only ER positivity were associated with the mast cell positivity. To conclude stromal mast cells has association with low-grade tumour and ER positive tumour which in turn suggested good prognosis.
|
|
[ FULL
TEXT ] | [ ]
|
|
Print
|
|